![]() ![]() ![]() is a privately held advanced biomaterials manufacturer located in Austin Texas. DiFusion has developed multiple internationally patented MITA Technologies (Metallic Ion Therapeutic Agents) for bone growth, tissue regeneration, antimicrobial, cellular repair, scaffold construction and increased angiogenesis. Our first product ZFUZE™* was developed as a load-bearing osteoconductive biomaterial platform for orthopedic applications, proven highly successful in 2 large animal studies. ZFUZE™ is currently being scaled up for commercial launch in early 2019. ZFUZE biomaterial will be submitted to FDA in early October 2018. 7 Department of Immunology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan.Ħ Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Dorsoduro 2137, 30123, Venezia, Italy.5 Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan.4 Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kamigyo-ku, 465 Kajii-cho, Kawaramachi dori, 602-0841, Kyoto, Japan.3 The Center for Advanced Medical Engineering and Informatics, Osaka University, Yamadaoka, Suita, 565-0871, Osaka, Japan.2 Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan.1 Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8585, Kyoto, Japan.ZFUZE and MATERIALS MATTER are registered trademarks of DiFusion Inc.8 Functional Composite Material Laboratory, Otsuka Chemical Co., Ltd., 2-2 Tsukasa-cho, Chiyoda-ku, 101-0048, Tokyo, Japan.9 Market and Research Department, Otsuka Chemical Co., Ltd., 2-2 Tsukasa-cho, Chiyoda-ku, 101-0048, Tokyo, Japan.10 Amedica Corporation, 1885 West 2100 South, Salt Lake City, UT, 84119, USA.11 Department of Orthopaedic Surgery, University of Missouri, Columbia, MO, 65212, USA.Polyetheretherketone (PEEK) is a popular polymeric biomaterial which is primarily used as an intervertebral spacer in spinal fusion surgery but it is developed for trauma, prosthodontics, maxillofacial, and cranial implants. It has the purported advantages of an elastic modulus which is similar to native bone and it can be easily formed into custom 3D shapes. Nevertheless, PEEK's disadvantages include its poor antibacterial resistance, lack of bioactivity, and radiographic transparency. ![]()
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